Promethazine HCl and Codeine Phosphate Oral Solution needs to be made use of with caution in sufferers with intense impairment of renal functionality, and patients needs to be monitored closely for respiratory melancholy, sedation, and hypotension.
Promethazine administered to the Expecting lady in just two months of supply may well inhibit platelet aggregation inside the newborn.
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Promethazine and codeine blend is made use of To ease cough, runny or stuffy nose, sneezing, or other signs and symptoms caused by allergies or even the popular chilly.
Promethazine should not be employed by small children young than 2 yrs because it may well cause really serious (quite possibly fatal) sluggish/shallow respiratory. This problem has transpired even with normal doses On this age group.
Pregnancy Assessments: Diagnostic pregnancy tests dependant on immunological reactions among HCG and anti-HCG could lead to Wrong-adverse or Untrue-optimistic interpretations.
Disposal of Unused Promethazine HCl and Codeine Phosphate Oral Remedy Advise people to correctly dispose of unused Promethazine HCl and Codeine Phosphate Oral Alternative. Suggest clients to throw the drug during the home trash subsequent these methods. 1) Clear away them from their unique containers and mix them using an undesirable compound, which include utilized espresso grounds or kitty litter (this helps make the drug less pleasing to children and pets, and unrecognizable to folks who might deliberately go in the trash trying to find medicine).
Your mouth may perhaps get dry. Chewing sugarless gum or sucking tough sweet and drinking a good amount of drinking water may perhaps assistance. Call your treatment team if the situation would not go away or is critical.
Promethazine HCl and Codeine Phosphate Oral Resolution ought to be utilized with caution in people with bone- marrow depression. Leukopenia and agranulocytosis happen to be described, generally when promethazine has become Employed in association with other acknowledged marrow-harmful agents.
If adrenal insufficiency is diagnosed, deal with with physiologic substitute doses of corticosteroids. Wean the affected person off from the opioid to allow adrenal functionality to recover and continue on corticosteroid cure until eventually adrenal purpose recovers. Other opioids could be experimented with as some cases noted usage of a different opioid with out recurrence of adrenal insufficiency. The information available would not recognize any particular opioids as remaining more prone to be related to adrenal insufficiency.
Mainly because opioid agonists Promethazine codeine syrup may well improve biliary tract stress, with resultant increase in plasma amylase or lipase levels, dedication of these enzyme ranges may very well be unreliable for 24 several hours following administration of the dose of Promethazine HCl and Codeine Phosphate Oral Option.
Respiratory depression resulting in arrest, coma, and Dying has transpired with the use of codeine antitussives in young small children, notably within the underneath-one-year infants whose capacity to deactivate the drug just isn't thoroughly designed.
Codeine can result in major unwanted results if taken by adults, young children, or pets who are not utilized to solid narcotic suffering medicines. You should definitely retail store the medicine in a secure and protected location to avoid Other folks from finding it. Drop off any unused narcotic medicine in a drug just take-back again location instantly.
When doctors prescribe codeine-that contains medicine, they ought to pick the lowest powerful dose for your shortest time period and should advise their patients about these challenges along with the indications of morphine overdose (see Safety measures - Nursing Mothers).